Chromatrap® Lysis buffer for sonication provides users with a detergent based buffer ideal for the fragmentation of samples by sonication. The optimised buffer composition ensures effective nuclear lysis for a range of different species of organism and difficult to lyse cell types and tissues. Correct shearing is critical to the success of a ChIP assay. The buffer is compatible with all Chromatrap® ChIP kits for sonication from fixed cells or tissue.