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ChIP Validated Antibodies

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The use of high quality and specific ChIP validated antibodies is essential for the success of a ChIP assay. The antibody must recognise and bind to native protein that is bound to DNA. Antibodies from other applications do not always work well in ChIP.

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Mouse Anti-Histone H3
Product Code : 700000
$368.40
Mouse Anti-Histone H3
Product Code : 700000
Download Datasheet

Histone 3 (H3) one of the core histone proteins, comprising the protein component of chromatin. H3 is ubiquitous within chromosomes and can be found bound to most gene sequences throughout the genome. It therefore serves as an abundant antibody target for ChIP and recognises the C-terminal peptide of human histone H3.

  • Applications: ChIP, WB, IP
  • Source: Mouse
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100μl
  • Purification: Protein G (affinity purified)
  • Specificity: Mouse, Human, Yeast
  • Storage: -20°C (Avoid multiple free/thaw cycles as this may denature the antibody)
Mouse Anti‐RNA polymerase II CTD repeat YSPTSPS (phospho S)
Product Code : 700001
$368.40
Mouse Anti‐RNA polymerase II CTD repeat YSPTSPS (phospho S)
Product Code : 700001
Download Datasheet

RNA polymerase II catalyzes the transcription of DNA into mRNA and other small nuclear RNAs in eukaryotes. It contains a CTD consisting of conserved heptapeptide repeats. Phosphorylation occurs at serine and therine residues located in the CTD repeats to activate the RNA pol II.

RNA pol II binds to several transcription factors in order to initiate transcription and therefore serves as an abundant antibody target for ChIP. This antibody recognises the C-terminal repeat of the largest subunit of RNA polymerase II. It recognises both unphosphorylated and phosphorylated form.

  • Applications: ChIP, WB, ELISA, ICC, IP, Flow Cyt
  • Source: Mouse
  • Concentration:8mg/ml
  • Type: Monoclonal
  • Size: 100μl
  • Purification: Protein A (affinity purified)
  • Specificity: Mouse, Human, Saccharomyces cerevisiae, Arabidopsis thaliana, Caenorhabditis elegans, Fruit fly (Drosophila melanogaster), Schizososaccharomyces pombe, African Green Monkey
  • Storage: -20°C (Avoid multiple free/thaw cycles as this may denature the antibody)
Mouse Anti-Histone H3 (tri methyl K9) [Clone 6F12-H4]
Product Code : 700003
$368.40
Mouse Anti-Histone H3 (tri methyl K9) [Clone 6F12-H4]
Product Code : 700003
Download Datasheet

Histone 3 tri methyl K9 (H3K9me3) is a histone mark associated with repressed chromatin. It condenses and compacts the chromatin, restricting the transcription machinery from binding and carrying out gene expression. It is a marker of constitutive heterochromatin, and generally associated with gene silencing.

As a histone mark, it is widely found throughout human cell lines, serving as an abundant antibody target for ChIP. This antibody recognises the synthetic peptide of Human Histone H3, tri methylated at K9. 

  • Applications: ChIP, WB, Dot blot, ELISA
  • Source: Mouse
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100μl
  • Purification: Protein G (affinity purified)
  • Specificity: Human, Cow. Predicted to detect many other species due to sequence identity such as Mouse, Rat, Rabbit, Hamster, Pig, Saccharomyces cerevisiae, Fruit fly (Drosophila melanogaster), Non Human Primates
  • Storage: -20°C (Avoid multiple free/thaw cycles as this may denature the antibody)
Anti 5-Methylcytosine
Product Code : 700005
$420.00
Anti 5-Methylcytosine
Product Code : 700005
Download Datasheet

5mC (5-Methylcytosine) is a region of DNA that has been epigenetically modified through the addition of a methyl group at the 5th carbon position of cytosine. DNA methylation is a repressive histone modification that is associated with switching off gene expression. This methylation generally occurs at CpG islands and is also associated with genomic imprinting. Aberrant DNA methylation is linked to disease including many cancers.

  • Applications: MeDIP
  • Source: Mouse
  • Concentration: 2mg/ml
  • Type: Monoclonal
  • Size: 50μl
  • Purification: Protein G (affinity purified)
  • Specificity: Human, mouse
  • Storage: -20°C (Avoid multiple free/thaw cycles as this may denature the antibody)
Anti Acetyl-H3
Product Code : 700006
$368.40
Anti Acetyl-H3
Product Code : 700006
Download Datasheet

Histone 3 (H3) is one of the core histone proteins, comprising the protein component of chromatin. H3 is ubiquitous within chromosomes and can be found bound to most gene sequences throughout the genome. Acetylation of histone H3 occurs at several different lysine positions on the histone tail and is catalysed by a group of enzymes called histone acetyltransferases (HATs). Histone acetylation is associated with active transcription through its roles in chromatin remodelling and gene activation.

This antibody recognises the human AcH3 protein.

  • Applications: ChIP, WB, ELISA
  • Source: Sheep
  • Concentration: 1mg/ml
  • Type: Polyclonal
  • Size: 100μl
  • Purification: Protein G (affinity purified)
  • Specificity: Human
  • Storage: +2- +8°C
Anti-Acetyl H4
Product Code : 700007
$368.40
Anti-Acetyl H4
Product Code : 700007
Download Datasheet

Histone 4 (H4) is one of the core histone proteins, comprising the protein component of chromatin. It is the smallest subunit of chromatin. Acetylation of histone H4 occurs at several different lysine positions on the histone tail and is catalysed by a group of enzymes called histone acetyltransferases (HATs). Histone acetylation is associated with active transcription.

Immunogen recognises human Histone 4 protein acetylated at lysines 5, 8, 12 and 16.

  • Applications: ChIP, WB, IHC, ELISA
  • Source: Sheep
  • Concentration: 1mg/ml
  • Type: Polyclonal
  • Size: 100μl
  • Purification: Protein G (affinity purified)
  • Specificity: Human
  • Storage: +2- +8°C
Anti-Androgen Receptor (AR)
Product Code : 700008
$368.40
Anti-Androgen Receptor (AR)
Product Code : 700008
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The androgen receptor (AR) is a steroid hormone receptor involved in the signaling of testosterone. It is a regulatory gene that controls gene expression through binding to androgen receptor elements (AREs). The AR is associated with both normal prostate and cancerous prostate cell growth at abnormal levels of the gene (Lamb et al, 2014, BJUI). Androgens are also heavily involved in the pathogenesis of endometrial cancer (D.A. Gibson et al, 2014, Endocr Relat Cancer). DHT (dihydrotestosterone) is a natural androgen hormone that can activate the androgen receptor (Mostaghel, 2014, IJBS).

This antibody recognises peptide sequence at the N-terminus of AR of human origin.

  • Applications: ChIP
  • Source: Sheep
  • Concentration: 1mg/ml
  • Type: Polyclonal
  • Size: 100μl
  • Purification: Protein G (affinity purified)
  • Specificity: Human
  • Storage: +2- +8°C (Do not freeze as this may denature the antibody)
Anti-Sin3a
Product Code : 700009
$368.40
Anti-Sin3a
Product Code : 700009
Download Datasheet

Sin3a (Switch independent 3 homologue) is a transcriptional repressor and protein-encoding gene. It interacts with co-repressors and DNA-binding proteins such as REST, MXl1 and MXD1-MAX that allow Sin3a to bind to DNA and repress transcriptional activity. It acts interdependently with OGT (O-linked N-acetylglucosamine) to repress transcription alongside with histone deacetylation.

This antibody recognises human Sin3a protein.

  • Applications: ChIP
  • Source: Sheep
  • Concentration: 1mg/ml
  • Type: Polyclonal
  • Size: 100μl
  • Purification: Protein G (affinity purified)
  • Specificity: Human
  • Storage: +2- +8°C (Do not freeze as this may denature the antibody)
Anti-Trimethyl-Histone H3 (Lys4) antibody, Clone RM137 H3K4me3
Product Code : 700010
$393.60
Anti-Trimethyl-Histone H3 (Lys4) antibody, Clone RM137 H3K4me3
Product Code : 700010
Download Datasheet

Histone 3 (H3) is one of the core histone proteins, comprising the protein component of chromatin. H3 is ubiquitous within chromosomes and can be found bound to most gene sequences throughout the genome. Tri-methylation of lysine 4 is associated with transcriptional start sites and gene activation.

This antibody recognizes a peptide corresponding to trimethyl-histone H3 (Lys 4).

  • Applications: ChIP, WB, ELISA, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100μl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: +2- +8°C
Anti-Acetyl-Histone H3 (Lys27) antibody, Clone RM172 H3K27ac
Product Code : 700011
$393.60
Anti-Acetyl-Histone H3 (Lys27) antibody, Clone RM172 H3K27ac
Product Code : 700011
Download Datasheet

Histone 3 (H3) is one of the core histone proteins, comprising the protein component of chromatin. H3 is ubiquitous within chromosomes and can be found bound to most gene sequences throughout the genome. Acetylation of histone H3 occurs at several different lysine positions on the histone tail and is catalysed by a group of enzymes called histone acetyltransferases (HATs). The acetylation of lysine 27 on histone 3 can be used to identify active enhancer sites, separating them from poised enhancers. Histone acetylation is associated with active transcription through its roles in chromatin remodelling and gene activation.

This antibody recognises an acetyl-peptide corresponding to the Acetyl-Histone H3 (Lys 27).

  • Applications: ChIP, WB, ELISA, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100μl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: +2- +8°C
Anti-Acetyl-Histone H3 (Lys14) antibody, Clone RM130 H3K14ac
Product Code : 700012
$393.60
Anti-Acetyl-Histone H3 (Lys14) antibody, Clone RM130 H3K14ac
Product Code : 700012
Download Datasheet

Histone 3 (H3) is one of the core histone proteins, comprising the protein component of chromatin. H3 is ubiquitous within chromosomes and can be found bound to most gene sequences throughout the genome. Acetylation of histone H3 occurs at several different lysine positions on the histone tail and is catalysed by a group of enzymes called histone acetyltransferases (HATs). The histone acetylation mark H3K14ac can indicate enhancer sites; helping to identify active enhancers from poised ones. H3K14ac is associated with active transcription and can be found at the start site of actively transcribed genes.

This antibody recognises an acetyl-peptide corresponding to the Acetyl-Histone H3 (Lys 14).

  • Applications: ChIP, WB, ELISA, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100μl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: +2- +8°C
Anti-Trimethyl-Histone H3 (Lys27) antibody, Clone RM17 H3K27me3
Product Code : 700013
$393.60
Anti-Trimethyl-Histone H3 (Lys27) antibody, Clone RM17 H3K27me3
Product Code : 700013
Download Datasheet

Histone 3 (H3) is one of the core histone proteins, comprising the protein component of chromatin. H3 is ubiquitous within chromosomes and can be found bound to most gene sequences throughout the genome. H3K27me3 is a histone mark associated with repressive transcription and a closed chromatin structure.

This antibody recognises a trimethyl-peptide corresponding to trimethyl-Histone H3 (Lys 27).

  • Applications: ChIP, WB, ELISA, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100μl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: -20°C
Rabbit IgG
Product Code : 700014
$75.60
Rabbit IgG
Product Code : 700014
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Immunoglobulin G (IgG) is an antibody isotype. It is comprised of two antigen binding sites and is created and released by plasma B cells. Purified rabbit IgG is used as a negative experimental control in many applications including Chromatin Immunoprecipitation (ChIP).

Immunogen is Rabbit IgG, polyclonal, isotype control.

  • Applications: ChIP, ChIP‐seq, WB
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Purified protein from rabbit serum
  • Size: 1ml
  • Purification: Affinity purified
  • Specificity: Rabbit
  • Storage: +2- +8°C
Sheep IgG
Product Code : 700015
$75.60
Sheep IgG
Product Code : 700015
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Immunoglobulin G (IgG) is an antibody isotype. It is comprised of two antigen binding sites and is created and released by plasma B cells. Purified sheep IgG is used as a negative experimental control in many applications including chromatin immunoprecipitation (ChIP).

Immunogen is Sheep IgG, polyclonal, isotype control.

  • Applications: ChIP, ChIP-seq, WB
  • Source: Sheep
  • Concentration: 1mg/ml
  • Type: IgG1/IgG2 isotypes
  • Size: 1ml
  • Purification: Affinity purified
  • Specificity: Sheep
  • Storage: +2‐ +8°C
Anti-Monomethyl-Histone H3 (Lys4) , antibod H3K4me1
Product Code : 700016
$393.60
Anti-Monomethyl-Histone H3 (Lys4) , antibod H3K4me1
Product Code : 700016
Download Datasheet

Histone 3 (H3) is one of the core histone proteins, comprising the protein component of chromatin. H3 is ubiquitous within chromosomes and can be found bound to most gene sequences throughout the genome. Monomethlyation of lysine 4 on histone 4 (H3K4me1) is a histone modification associated with open chromatin and active transcription. The presence of H3K4me1 generally indicates an enhancer region of DNA.

  • Applications: ChIP, WB, ELISA, Multiplex
  • ICC Source: Rabbit Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100µl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: +2-+8°C
Anti-Acetyl-Histone H4 (Lys5) antibody, Clone RM199 H4K5ac
Product Code : 700017
$393.60
Anti-Acetyl-Histone H4 (Lys5) antibody, Clone RM199 H4K5ac
Product Code : 700017
Download Datasheet

Histone 4 (H4) is one of the five core histone proteins, comprising the protein component of chromatin. H4 is ubiquitous within chromosomes and can be found bound to most gene sequences throughout the genome. Acetylation of lysine 5 on histone 4 (H4K5ac) is associated with open chromatin and active gene transcription. H4K5ac has been shown to have roles in epigenetic bookmarking, a process where genetic information is passed onto daughter cells during cell division.

  •  Applications: ChIP, WB, ELISA, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100μl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: +2-+8°C
Anti-Acetyl-Histone H4 (Lys12) antibody, Clone RM202 H4K12ac
Product Code : 700018
$393.60
Anti-Acetyl-Histone H4 (Lys12) antibody, Clone RM202 H4K12ac
Product Code : 700018
Download Datasheet

Histone 4 (H4) is one of the core histone proteins, comprising the protein component of chromatin. H4 is ubiquitous within chromosomes and can be found bound to most gene sequences throughout the genome. Lysine 12 on histone 4 (H4K12) can only be acetylated and is not associated with methylation. The histone modification H4K12ac is associated with active promoter regions and has roles in activating the transcription of genes, in particular genes with roles in memory and learning. H4K12ac can have an influence on paternal inheritance in the zygote, indicating the importance of this mark for embryo development.  

  • Applications: ChIP, WB, ELISA, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100µl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: +2- +8°C
Anti-­‐Histone H2Az, Clone RM215
Product Code : 700019
$393.60
Anti-­‐Histone H2Az, Clone RM215
Product Code : 700019
Download Datasheet

Histone H2A (H2A) is one of the four core histone proteins, comprising the protein component of chromatin. The core histones are responsible for the structure and shape of nucleosomes. H2Az is a variant of H2A. It is associated with memory and regulates gene transcription in the brain. For this reason it has been put forward as a potential therapeutic target for memory disorders (Zovkic et al. 2014). H2Az can be found bound to most gene sequences throughout the genome. It therefore serves as an abundant antibody target for ChIP.

  • Applications: ChIP, WB, ELISA, ICC, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100µl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: -20°C
Anti-­‐Histone H3, Clone RM188
Product Code : 700020
$393.60
Anti-­‐Histone H3, Clone RM188
Product Code : 700020
Download Datasheet

Histone 3 (H3) one of the core histone proteins, comprising the protein component of chromatin. H3 is ubiquitous within chromosomes and can be found bound to most gene sequences throughout the genome. It therefore serves as an abundant antibody target for ChIP.

  • Applications: ChIP, WB, ELISA, ICC, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100µl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: +2 - + 8°C
Anti-­‐Histone H4, Clone RM212
Product Code : 700021
$393.60
Anti-­‐Histone H4, Clone RM212
Product Code : 700021
Download Datasheet

Histone 4 (H4) is one of the core histone proteins, comprising the protein component of chromatin. H4 is involved in the structure of chromosomes and can be found bound to most gene sequences throughout the genome. It therefore serves as an abundant antibody target for ChIP.

  • Applications: ChIP, WB, ELISA, ICC, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100µl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: -20°C
Anti-Monomethyl Histone H3 (Lys 9) [Clone RM150]
Product Code : 700022
$393.60
Anti-Monomethyl Histone H3 (Lys 9) [Clone RM150]
Product Code : 700022
Download Datasheet

Histone 3 is one of the core histone proteins, comprising the protein component of chromatin. Histones 3 monomethyl lysine 9 (H3K9me1) is a histone mark associated with gene activation. It is enriched at the transcriptional start site of genes and is detected in active gene promoters, where it can characterise active gene transcription.

  • Applications: ChIP, WB, ICC, ELISA, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100μl
  • Purification: Protein A (affinity purified)
  • Specificity: Human
  • Storage: +4°C
Rabbit Anti-Histone H3 (di methyl K9) [Clone RM151]
Product Code : 700023
$393.60
Rabbit Anti-Histone H3 (di methyl K9) [Clone RM151]
Product Code : 700023
Download Datasheet

Histone 3 is one of the core histone proteins, comprising the protein component of chromatin. Histone 3 tri methyl K9 (H3K9me2) is a histone mark generally associated with repressed chromatin. It condenses and compacts the chromatin, restricting the transcription machinery from binding and carrying out gene expression. It is often found at silenced genes and is a mark of transcriptional repression.

  • Applications: ChIP, WB, ICC, ELISA, Multiplex
  • Source: Rabbit
  • Concentration: 1mg/ml
  • Type: Monoclonal
  • Size: 100ul
  • Purification: Protein G (affinity purified)
  • Specificity: Human
  • Storage: +4°C
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